UNIVERSITAS AIRLANGGA



Detail Article

Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 6 / No. 1 / Published : 2008-04

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Original Article :

Efect  of al(oh)3 and mg(oh)2 suspesion dosage form on the absorption of oral ciprofloxacin

Author :

  1. Aniek Setiya Budiatin*1
  2. Nunik Wahyuni*2
  3. Suharyono*3
  4. Toetik Aryani*4
  1. Departemen Farmasi Klinis, Fakultas Farmasi Universitas Airlangga
  2. Departemen Farmasi Klinis, Fakultas Farmasi Universitas Airlangga
  3. Departemen Farmasi Klinis, Fakultas Farmasi Universitas Airlangga
  4. Departemen Farmasi Klinis, Fakultas Farmasi Universitas Airlangga

Abstract :

Potential interaction of fluroquinolone with other drugs have been established in the several reports. The absorption of fluroquinolones were almost entirely inhibited by concomitant administration of di and trivalent cations such magnesium and aluminium in the antacids were significantly decreased the absorption of ciprofloxacin through formation of a complex. The effect of antacid (Antasida DOEN) 1.4 ml/kg body weight doses which containing polyvalent cation Mg (OH)2 and Al(OH) 3 on the absorption of ciprofloxacin. were examed in healthy rabbit. Twelve subjects were given 23 mg/ml BW ciprofloxacin alone as control. On day 8 the six subjects were given antacid and ciprofloxacin concomitant and the other were given antacid two hours after ciprofloxacin. The absorption parameters of ciprofloxacin were determined by spectrofluorometric method. Those parameters were Cmax, tmax and AUC, the administration of ciprofloxacin and antacids concomitantly result Cmax, tmax and AUC were 1.27±0.45mg/ml; 110±48.99 minutes and 248.63±94.77mg.minutes/ml respectively  in a significant decrease in ciprofloxacin absorption (p<0.05) and the administration of antacids  two hours after ciprofloxacin result Cmax, tmax and AUC were 1.37±0.65mg/ml;75±36.74 minutes and 245.09±100.46 mg.minutes/ml respectively  in a significant decrease in ciprofloxacin absorption (p<0.05). Percentages of relative bioavailability compared with control values were 27.06±16.70% and 8.77±6.97%  for concomitant and  two hours after ciprofloxacin respectively.

Keyword :

Ciprofloxacin, Mg(OH)2 , Al(OH)3 , antacid, Spectrofluorometric ,


References :

Ball, P,(2000) The Quinolones History and Overview. In: Vincent T. Andriole (Eds) London : The Quinolones, London: Academic Press

Katherine E.Brighty dan Thomas D Gootz,(2000) Chemistry and Mechanism of action of the Quinolone antibacterials. In: Vincent T. Andriole (Eds). London : The Quinolones, London: Academic Press

El-Kommos M.E.; Saleh G.A.; El-Gizawi S.M.; Abou-Elwafa M.A.,(2003) Talanta vol 60. Spectrofluorometric Determination of Certain Quinolone Antibacterial Using Metal Chelation. Talanta,Vol. 60 London : Elsevier

Fish DN, Chow AT.,(1997) The Clinical Pharmacokinetics of Levofloxacin. Clin Pharmacoki net., Vol. 2 No. 32 US : Pum Med

McEvoy GK,(2002) AHFS Drug Information American Society of Health System Biopharmacuetics & Pharmacokinetics 5th Ed., USA : American Society of Health System Pharmacist, Inc., US : Amer Soc of Health System

David E Nix , William A Watson , Michelle E Lener , R Wayne Frost PharmD, George Krol PhD, Harvey Go,(1989



Archive Article

Cover Media Content

Volume : 6 / No. : 1 / Pub. : 2008-04
  1. Efect  Of Al(oh)3 And Mg(oh)2 Suspesion Dosage Form On The Absorption Of Oral Ciprofloxacin
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